According to the study results presented at the 2018 Genitourinary Cancers Symposium, the risk of rectal toxicity and recurrence of cancer is greatly reduced by the daily image-guided radiotherapy (IGRT); the IGRT increases the chances of one being infected by a second form of cancer. The optimal frequency of cancer control is not well identified although there exists a solid rational for prostate cancer IGRT. This is according to the research done by one a radiation-oncologist, Prof Renaud de Crevoisier at the University of Rennes. Doing a control on three consecutive days or weekly makes it possible to correct for the systematic error only. To correct for random and systematic error, daily control is recommendable.
Two steps – According to the research done by Prof Renaud, only two steps are included in the phase-3 randomizedtrial. The first step involved carrying out the feasibility test for at least five patients. The next step involved about 470 cancer patients from around 21 centers who would be randomized in the ratio of 1:1: this involved daily or weekly control in the period 2007-2012. Findings – The reason for carrying out the two-step analysis was to find out any significant differences (at least 12.0%) within the five-year disease free survival (DFS). In this study, it was established that there was a general OS decrement in the daily control group while the risk of the patient’s death was doubled. The risk of experiencing a second cancer infection was also multiplied by two in the post-hoc analysis of the research. Even though it is associated with the risk of a second cancer infection, by enhancing targeting, the daily control in prostate cancer IGRT is ideal in reducing the risk of cancer recurrence and rectal toxicity. However, in order to assess the rate of radiation-associated malignancies, longer follow-up is clearly needed. About Author Dr. Echt and his team at the Prostate Seed Institute offer the most highly sophisticated methods of radiation therapy available in the United States, equal to that found in major medical center and academic settings. These include prostate seed implantation, high dose radiation implants, and external beam radiation with image-guided and intensity-modulated (IGRT and IMRT) capabilities.