The etiology is very complex, and it’s main caused by pathogen infection, inflammation and abnormal neuromuscular activity in pelvic floor and abnormal immune. 1.pathogen infection. Although this type of patient fails to isolate the pathogen by routine bacterial examination, it may still be associated with certain specific pathogens such as anaerobic bacteria, L-formed bacteria, nanobacteria, or Chlamydia trachomatis, Mycoplasma and other infections. Studies have shown that the local prokaryotic DNA detection rate of this type of patients can be as high as 77%; some clinically, “aseptic” prostatitis with chronic inflammation, recurrent or aggravated may be related to these pathogens. Other pathogens such as parasites, fungi, viruses, trichomoniasis, Mycobacterium tuberculosis, etc. may also be important pathogenic factors of this type, but lack reliable evidence, so there is no consensus. 2.Micturition dysfunction. Some factors cause excessive contraction of the urethral sphincter, that leading to bladder outlet obstruction and residual urine formation, causing urine to flow back into the prostate, it not only bringing the pathogen into the prostate, but also directly stimulating the prostate, inducing sterile “chemical prostatitis”. Causes abnormal urination and pain in the pelvic region. Many prostatitis patients have a variety of urodynamic changes, such as: decreased urine flow rate, functional urinary tract obstruction, detrusor-urethral sphincter dyssynergia. These functional abnormalities may be related to a variety of potential pathogenic factors. 3.Psycho psychological factors. More than half of patients with prolonged prostatitis have significant changes in mental and psychological factors and personality traits. Such as: anxiety, depression, suspected illness, rickets. These changes in mental and psychological factors can cause autonomic dysfunction, resulting in dysfunction of the posterior urethral neuromuscular, leading to pain in the pelvic region and dysfunction of urination; or causing changes in the function of the hypothalamic-pituitary-gonadal axis, which may affect sexual function and further aggravate symptoms. Eliminate mental stress can relieve symptoms and cure it. 4.Abnormal immune response. Recent studies have shown that immune factors play a very important role in the progression of prostatitis. cell factor of changes can occur in the prostatic fluid, seminal plasma, tissue, blood of patients. Patients can use some drugs to improve immune. 5.Pelvic related diseases. Some patients with prostatitis often have peripheral venous plexus dilatation, Hemorrhoids, varicocele, etc., suggesting that some patients with chronic prostatitis may be associated with pelvic venous congestion and blood stasis, which may be one of the causes of long-term cure.